Article
A genome wide association study suggests the association of muskelin with early onset bipolar disorder: Implications for a GABAergic epileptogenic neurogenesis model.
Journal of affective disorders - 15 Jan 2017
Nassan Malik, Li Qingqin, Croarkin Paul E, Chen Wenan, Colby Colin L, Veldic Marin, McElroy Susan L, Jenkins Gregory D, Ryu Euijung, Cunningham Julie M, Leboyer Marion, Frye Mark A, Biernacka Joanna M
Abstract excerpt
BACKGROUND: Although multiple genes have been implicated in bipolar disorder (BD), they explain only a small proportion of its heritability. Identifying additional BD risk variants may be impaired by phenotypic heterogeneity, which is usually not taken into account in genome-wide association studies (GWAS). BD with early age at onset is a more homogeneous familial form of the disorder associated with greater...
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