Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain.

Cell reports - 18 Oct 2016

Bhattarai Prabesh, Thomas Alvin Kuriakose, Cosacak Mehmet Ilyas, Papadimitriou Christos, Mashkaryan Violeta, Froc Cynthia, Reinhardt Susanne, Kurth Thomas, Dahl Andreas, Zhang Yixin, Kizil Caghan

Abstract excerpt

Human brains are prone to neurodegeneration, given that endogenous neural stem/progenitor cells (NSPCs) fail to support neurogenesis. To investigate the molecular programs potentially mediating neurodegeneration-induced NSPC plasticity in regenerating organisms, we generated an Amyloid-β42 (Aβ42)-dependent neurotoxic model in adult zebrafish brain through cerebroventricular microinjection of cell-penetrating Aβ42...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Plasticity
Share to Interleukin-4

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microglia

Share to Nerve Degeneration

Share to Neural Stem Cells

Share to Neurogenesis

Share to Protein Aggregates

Share to STAT6 Transcription Factor

Source

Identifiers

PMID: 27760324
DOI: 10.1016/j.celrep.2016.09.075

Genes

STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain.PMID 27760324Read ↗

Single cell analyses of the effects of Amyloid-beta42 and Interleukin-4 on neural stem/progenitor cell plasticity in adult zebrafish brainSemantic proximity Read ↗

Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer’s model of adult zebrafish brainSemantic proximity Read ↗

Human neural stem cells restore spatial memory in a transgenic Alzheimer’s disease mouse model by an immunomodulating mechanismSemantic proximity Read ↗

Interleukin-4 restores neurogenic plasticity of the primary human neural stem cells through suppression of Kynurenic acid production upon Amyloid-beta42 toxicitySemantic proximity Read ↗

An Integrated Neuroimmune Assembloid Model to Advance Neurodegenerative Disease StudiesSemantic proximity Read ↗

Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signaling, in Aged HippocampusSemantic proximity Read ↗

Transplantation of wild-type hematopoietic stem and progenitor cells rescue Alzheimer’s disease in a mouse model and highlights the central role of microglia in disease pathogenesisSemantic proximity Read ↗

Hematopoietic stem cell gene therapy to halt neurodegenerationSemantic proximity Read ↗

Rescue of Alzheimer's disease phenotype in a mouse model by transplantation of wild-type hematopoietic stem and progenitor cells.Semantic proximity Read ↗

A novel monomeric amyloid β-activated signaling pathway regulates brain development via inhibition of microgliaSemantic proximity Read ↗

All-trans retinoic acid improved impaired proliferation of neural stem cells and suppressed microglial activation in the hippocampus in an Alzheimer's mouse model.Semantic proximity Read ↗

Stem cell therapy offers new hope for the treatment of Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.