Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing.

Endocrinology - 1 Dec 2016

Pilbrow Anna P, Lewis Kathy A, Perrin Marilyn H, Sweet Wendy E, Moravec Christine S, Tang W H Wilson, Huising Mark O, Troughton Richard W, Cameron Vicky A

Abstract excerpt

Corticotropin-releasing factor (CRF) and the CRF-related peptides, urocortin (Ucn)-1, Ucn2, and Ucn3 signal through receptors CRFR1 and CRFR2 to restore homeostasis in response to stress. The Ucns exert potent cardioprotective effects and may have clinical utility in heart failure. To explore the activity of this system in the heart, we measured the levels of myocardial gene expression of the CRF/Ucn family of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Corticotropin-Releasing Hormone

Share to CRF Receptor, Type 1

Share to Heart Failure

Share to Myocardium

Share to Receptors, Corticotropin-Releasing Hormone

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 27754786
DOI: 10.1210/en.2016-1448
PMCID: PMC5133347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing.PMID 27754786Read ↗

Corticotropin-Releasing Factor Family: A Stress Hormone-Receptor System’s Emerging Role in Mediating Sex-Specific SignalingSemantic proximity Read ↗

Emerging role of alternative splicing of CRF1 receptor in CRF signaling.Semantic proximity Read ↗

The Corticotropin-Releasing Factor Family: Physiology of the Stress ResponseSemantic proximity Read ↗

Plasma Long Noncoding RNA Urothelial Carcinoma Associated 1 Predicts Poor Prognosis in Chronic Heart Failure PatientsSemantic proximity Read ↗

A novel corticotropin‐releasing factor receptor splice variant exhibits dominant negative activity: a putative link to stress‐induced heart diseaseSemantic proximity Read ↗

A novel agonist antibody to membrane-bound guanylate cyclase receptor, natriuretic peptide receptor 1, induces sustained vasodilationSemantic proximity Read ↗

Promoter Analysis of Human Corticotropin-Releasing Factor (CRF) Type 1 Receptor and Regulation by CRF and UrocortinSemantic proximity Read ↗

α1-Adrenergic Receptor Subtypes in Nonfailing and Failing Human MyocardiumSemantic proximity Read ↗

The three-dimensional structure of the N-terminal domain of corticotropin-releasing factor receptors: sushi domains and the B1 family of G protein-coupled receptors.Semantic proximity Read ↗

Common variations in noncoding regions of the human natriuretic peptide receptor A gene have quantitative effects.Semantic proximity Read ↗

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptorSemantic proximity Read ↗

The genomic structure of the rat corticotropin releasing factor receptor. A member of the class II G protein-coupled receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.