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Article

A novel corticotropin‐releasing factor receptor splice variant exhibits dominant negative activity: a putative link to stress‐induced heart disease

26 Feb 2009

Abstract excerpt

A growing body of experimental and clinical studies supports a strong association between psychological stress and cardiovascular disease. An important endogenous cardioprotective role in heart physiology has been attributed to corticotropin-releasing factor receptor type 2beta (CRFR2beta). Here, we report the isolation of cDNA from mouse (m) heart encoding a novel CRFR2beta splice variant. Translation of this...

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PMID: 19246489
DOI: 10.1096/fj.08-128066

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