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Article

Methotrexate Triglutamate as a Determinant of Clinical Response in Mexican Patients With Rheumatoid Arthritis: Pharmacokinetics and Dose Recommendation.

Journal of clinical pharmacology - 1 Aug 2021

Huerta-García Ana P, Rodríguez-Báez Ana S, Medellín-Garibay Susanna E, Portales-Pérez Diana P, Martínez-Martínez Marco U, Abud-Mendoza Carlos, Herrera-Van Oostdam David, Romano-Moreno Silvia, Milán-Segovia Rosa Del C

Abstract excerpt

Methotrexate is the gold standard treatment in rheumatoid arthritis. Once absorbed, it is internalized in cells, where glutamate residues are added to produce polyglutamated forms, which are responsible for the effect of methotrexate. The aim of the current study is to determine the relationship between methotrexate triglutamate concentrations and the clinical evolution in rheumatoid arthritis patients, as well...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 33595870
DOI: 10.1002/jcph.1837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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