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Article

Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis.

Scientific reports - 17 Oct 2016

Laurent Michaël R, Hammond Geoffrey L, Blokland Marco, Jardí Ferran, Antonio Leen, Dubois Vanessa, Khalil Rougin, Sterk Saskia S, Gielen Evelien, Decallonne Brigitte, Carmeliet Geert, Kaufman Jean-Marc, Fiers Tom, Huhtaniemi Ilpo T, Vanderschueren Dirk, Claessens Frank

Abstract excerpt

Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens and estrogens. According to the free hormone hypothesis, SHBG modulates the bioactivity of sex steroids by limiting their diffusion into target tissues. Still, the in vivo physiological role of circulating SHBG remains unclear, especially since mice and rats lack circulating SHBG post-natally. To test the free hormone...

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Identifiers

PMID: 27748448
DOI: 10.1038/srep35539
PMCID: PMC5066276

Genes

SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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