Genome-Wide Association Study of Intracranial Artery Stenosis Followed by Phenome-Wide Association Study.

doi:10.1007/s12975-022-01049-w

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Genome-Wide Association Study of Intracranial Artery Stenosis Followed by Phenome-Wide Association Study.

Translational stroke research - 1 Jun 2023

Dofuku Shogo, Sonehara Kyuto, Miyawaki Satoru, Sakaue Saori, Imai Hideaki, Shimizu Masahiro, Hongo Hiroki, Shinya Yuki, Ohara Kenta, Teranishi Yu, Okano Atsushi, Ono Hideaki, Nakatomi Hirofumi, Teraoka Akira, Yamamoto Kenichi, Maeda Yuichi, Nii Takuro, Kishikawa Toshihiro, Suzuki Ken, Hirata Jun, Takahashi Meiko, Matsuda Koichi, Kumanogoh Atsushi, Matsuda Fumihiko, Okada Yukinori, Saito Nobuhito

Abstract excerpt

The genetic background of intracranial artery stenosis (ICAS), a major cause of ischemic stroke, remains elusive. We performed the world's first genome-wide association study (GWAS) of ICAS using DNA samples from Japanese subjects, to identify the genetic factors associated with ICAS and their correlation with clinical features. We also conducted a phenome-wide association study (PheWAS) of the top variant...

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PMID: 35701560
DOI: 10.1007/s12975-022-01049-w

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