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Article

Wide spetcrum mutational analysis of metastatic renal cell cancer: a retrospective next generation sequencing approach.

Oncotarget - 31 Jan 2017

Fiorentino Michelangelo, Gruppioni Elisa, Massari Francesco, Giunchi Francesca, Altimari Annalisa, Ciccarese Chiara, Bimbatti Davide, Scarpa Aldo, Iacovelli Roberto, Porta Camillo, Virinder Sarhadi, Tortora Giampaolo, Artibani Walter, Schiavina Riccardo, Ardizzoni Andrea, Brunelli Matteo, Knuutila Sakari, Martignoni Guido

Abstract excerpt

Renal cell cancer (RCC) is characterized by histological and molecular heterogeneity that may account for variable response to targeted therapies. We evaluated retrospectively with a next generation sequencing (NGS) approach using a pre-designed cancer panel the mutation burden of 32 lesions from 22 metastatic RCC patients treated with at least one tyrosine kinase or mTOR inhibitor. We identified mutations in the...

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Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27741505
DOI: 10.18632/oncotarget.12551
PMCID: PMC5352324

Genes

JAK3
PTEN
APC
EGFR
ERBB4
FGFR3
MET
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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