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Article

Whole-Exome Sequencing in Two Extreme Phenotypes of Response to VEGF-Targeted Therapies in Patients With Metastatic Clear Cell Renal Cell Carcinoma.

Journal of the National Comprehensive Cancer Network : JNCCN - 1 Jul 2016

Fay Andre P, de Velasco Guillermo, Ho Thai H, Van Allen Eliezer M, Murray Bradley, Albiges Laurence, Signoretti Sabina, Hakimi A Ari, Stanton Melissa L, Bellmunt Joaquim, McDermott David F, Atkins Michael B, Garraway Levi A, Kwiatkowski David J, Choueiri Toni K

Abstract excerpt

Advances in next-generation sequencing have provided a unique opportunity to understand the biology of disease and mechanisms of sensitivity or resistance to specific agents. Renal cell carcinoma (RCC) is a heterogeneous disease and highly variable clinical responses have been observed with vascular endothelial growth factor (VEGF)-targeted therapy (VEGF-TT). We hypothesized that whole-exome sequencing analysis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27407122
DOI: 10.6004/jnccn.2016.0086
PMCID: PMC5582541

Genes

PBRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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