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Article

Can pharmacogenetics help patients under chronic treatment with coumarin anticoagulants?

Drug metabolism and personalized therapy - 1 Dec 2016

López Isabel, Sangüesa Estela, Vancraenendonck Yves, Zuriaga Estefanía, Ribate María Pilar, García Cristina Belén

Abstract excerpt

Vitamin K antagonists are highly effective antithrombotic drugs. However, appropriate dosing is difficult to establish owing to its narrow therapeutic window as well as widespread inter- and intra-individual variability in dosage. Compared with dosing solely based on clinical information, pharmacogenetics can help improve the therapy with coumarins by decreasing the time to reach a stable dose and reducing the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27740916
DOI: 10.1515/dmpt-2016-0026

Genes

APOE
VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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