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Article

FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice.

Scientific reports - 14 Oct 2016

Kino Yoshihiro, Washizu Chika, Kurosawa Masaru, Yamada Mizuki, Doi Hiroshi, Takumi Toru, Adachi Hiroaki, Katsuno Masahisa, Sobue Gen, Hicks Geoffrey G, Hattori Nobutaka, Shimogori Tomomi, Nukina Nobuyuki

Abstract excerpt

FUS/TLS is an RNA/DNA-binding protein associated with neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Previously, we found that a prion-like domain in the N-terminus of FUS/TLS mediates co-aggregation between FUS/TLS and mutant huntingtin, the gene product of Huntington's disease (HD). Here, we show that heterozygous knockout of FUS/TLS worsened the...

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Source

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Identifiers

PMID: 27739513
DOI: 10.1038/srep35236
PMCID: PMC5064419

Genes

FUS
SDS
TAF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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