Whole-exome sequencing reveals mutational profiles of anorectal and gynecological melanoma

Abstract excerpt

<title>Abstract</title> <p>Mucosal melanoma is a rare and highly malignant type of melanoma. Among the sites that mucosal melanoma arises, anorectal and gynecological melanoma has more aggressive behavior and worse prognosis. There was no effective therapy for mucosal melanoma at present. Only a small number of mucosal melanoma patients which harbor mutations in <italic>BRAF</italic> or <italic>KIT</italic> benef...

Topics

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• Alternative Splicing
• Combined Modality Therapy
• Exome Sequencing
• Melanoma
• Mucous Membrane
• Mutation
• Prognosis
• Proto-Oncogene Proteins B-raf

Identifiers and source

Literature Corpus work

08cecd93-5d06-53cc-b348-23f3ba2c58c2

DOI

10.21203/rs.3.rs-2990916/v1