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Detecting mosaicism in trophectoderm biopsies: current challenges and future possibilities

13 Oct 2016

Abstract excerpt

Embryonic mosaicism, defined as the presence of karyotypically distinct cell lines within an embryo, has been frequently reported with a high incidence in preimplantation embryos derived from IVF and is thought to be one of the major biological limitations for the routine application of PGD for aneuploidies (PGD-A). The incidence of mosaicism in preimplantation embryos is in fact reported to be between 4 and 90%....

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PMID: 27738115
DOI: 10.1093/humrep/dew250

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