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Article

Expression pattern of key micro<scp>RNA</scp>s in patients with newly diagnosed chronic myeloid leukemia in chronic phase

2 Apr 2015

Abstract excerpt

INTRODUCTION: Chronic myeloid leukemia (CML) is caused by reciprocal translocation in hematopoietic stem cells (HSCs). This translocation forms the BCR-ABL1 oncogene, which alters several signaling pathways that control malignancy. CML has three phases: chronic, accelerated, and blast crisis. The microRNAs (miRNAs or miRs) are noncoding RNAs that downregulate their target gene by targeting 3' UTR of mRNA or...

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PMID: 25833191
DOI: 10.1111/ijlh.12351

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