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Article

Direct Conversion of Fibroblasts to Megakaryocyte Progenitors

1 Oct 2016

Abstract excerpt

, display polylobulated nuclei, have ploidies higher than 4N, form MK colonies, and give rise to platelets in vitro. Moreover, transplantation of MK-like murine progenitor cells into NSG mice results in successful engraftment and further maturation in vivo. Similar results are obtained using disease-corrected fibroblasts from Fanconi anemia patients. Our results combined demonstrate that functional MK progenitors...

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PMID: 27732845
DOI: 10.1016/j.celrep.2016.09.036

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