Genome-Wide Association Study Identifies ZNF354C Variants Associated with Depression from Interferon-Based Therapy for Chronic Hepatitis C.

doi:10.1371/journal.pone.0164418

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Article

Genome-Wide Association Study Identifies ZNF354C Variants Associated with Depression from Interferon-Based Therapy for Chronic Hepatitis C.

PloS one - 1 Jan 2016

Matsunami Kayoko, Nishida Nao, Kaneko Naoko, Ikeo Kazuho, Toyo-Oka Licht, Takeuchi Hiroshi, Matsuura Kentaro, Tamori Akihiro, Nomura Hideyuki, Yoshiji Hitoshi, Imamura Masatoshi, Masaki Naohiko, Hayakawa Tatsuro, Ide Tatsuya, Shimada Noritomo, Ikeda Fusao, Hino Keisuke, Nishiguchi Shuhei, Okuse Chiaki, Nojiri Shunsuke, Sawamoto Kazunobu, Tokunaga Katsushi, Joh Takashi, Tanaka Yasuhito

Abstract excerpt

The therapeutic use of interferon (IFN) is known to cause depression that frequently interrupts treatment. To identify genetic variants associated with IFN-induced depression, we conducted a genome-wide association study (GWAS) of 224 Japanese chronic hepatitis C patients receiving IFN-based therapy in a multicenter prospective study and stratified them into two groups according to the Beck Depression Inventory,...

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PMID: 27723809
DOI: 10.1371/journal.pone.0164418
PMCID: PMC5056723

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