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Article

Isocitrate dehydrogenase mutations in myeloid malignancies.

Leukemia - 1 Feb 2017

Medeiros B C, Fathi A T, DiNardo C D, Pollyea D A, Chan S M, Swords R

Abstract excerpt

Alterations to genes involved in cellular metabolism and epigenetic regulation are implicated in the pathogenesis of myeloid malignancies. Recurring mutations in isocitrate dehydrogenase (IDH) genes are detected in approximately 20% of adult patients with acute myeloid leukemia (AML) and 5% of adults with myelodysplastic syndromes (MDS). IDH proteins are homodimeric enzymes involved in diverse cellular processes,...

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Source

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Identifiers

PMID: 27721426
DOI: 10.1038/leu.2016.275
PMCID: PMC5292675

Genes

IDH2
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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