Article
Clinical Response to Donepezil in Mild and Moderate Dementia: Relationship to Drug Plasma Concentration and CYP2D6 and APOE Genetic Polymorphisms.
Journal of Alzheimer's disease : JAD - 1 Jan 2017
Miranda Luís F J R, Gomes Karina B, Tito Pedro A L, Silveira Josianne N, Pianetti Gerson A, Byrro Ricardo M D, Peles Patrícia R H, Pereira Fernando H, Santos Thiago R, Assini Arthur G, Ribeiro Valéria V, Moraes Edgar N, Caramelli Paulo
Abstract excerpt
The clinical response to donepezil in patients with mild and moderate dementia was investigated in relation to the drug plasma concentration and APOE and CYP2D6 polymorphisms. In a prospective naturalistic observational study, 42 patients with Alzheimer's disease (AD) and AD with cerebrovascular disease who took donepezil (10 mg) for 12 months were evaluated. Their DNA was genotyped, and the donepezil plasma...
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