Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease.

doi:10.1212/WNL.0b013e3181b6bbe3

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Article

Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease.

Neurology - 8 Sept 2009

Pilotto Alberto, Franceschi M, D'Onofrio G, Bizzarro A, Mangialasche F, Cascavilla L, Paris F, Matera M G, Pilotto Andrea, Daniele A, Mecocci P, Masullo C, Dallapiccola B, Seripa D

Abstract excerpt

OBJECTIVE: To evaluate the influence of the single nucleotide polymorphism rs1080985 in the cytochrome P450 2D6 (CYP2D6) gene on the efficacy of donepezil in patients with mild to moderate Alzheimer disease (AD). METHODS: This was a multicenter, prospective cohort study of 127 white patients with AD according to the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and...

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PMID: 19738170
DOI: 10.1212/WNL.0b013e3181b6bbe3
PMCID: PMC2739607

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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