Article
Accuracy of p57KIP2 compared with genotyping for the diagnosis of complete hydatidiform mole: protocol for a systematic review and meta-analysis.
Systematic reviews - 4 Oct 2016
Madi Jose Mauro, Braga Antonio Rodrigues, Paganella Machline Paim, Litvin Isnard Elman, Da Ros Wendland Eliana Márcia
Abstract excerpt
BACKGROUND: Distinguishing hydatidiform moles (HMs) from non-molar specimens and the subclassification of HM are important because complete hydatidiform mole (CHM) is associated with an increased risk of gestational trophoblastic neoplasia. However, diagnosis based solely on morphology has poor interobserver reproducibility. Recent studies have demonstrated that the use of p57KIP2 immunostaining improves...
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