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Article

CGG repeat in the FMR1 gene: size matters.

Clinical genetics - 1 Sept 2011

Willemsen R, Levenga J, Oostra B A

Abstract excerpt

The FMR1 gene contains a CGG repeat present in the 5'-untranslated region which can be unstable upon transmission to the next generation. The repeat is up to 55 CGGs long in the normal population. In patients with fragile X syndrome (FXS), a repeat length exceeding 200 CGGs (full mutation: FM) generally leads to methylation of the repeat and the promoter region, which is accompanied by silencing of the FMR1 gene....

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Source

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Identifiers

PMID: 21651511
DOI: 10.1111/j.1399-0004.2011.01723.x
PMCID: PMC3151325

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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