Up‐regulation of micro RNA ‐491‐5p suppresses cell proliferation and promotes apoptosis by targeting FOXP 4 in human osteosarcoma

Abstract excerpt

BACKGROUND AND OBJECTIVES: MicroRNAs are small non-coding RNAs involved in pathogenesis and progression of human malignancies. MicroRNA-491-5p (miR-491-5p) is down-regulated in many human cancers where it would serve as a tumour suppressor. However, the role played by miR-491-5p in pathogenesis of human osteosarcoma has remained largely unknown. This study has been conducted to examine effects of miR-491-5p on...

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