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Article

Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS.

Acta neuropathologica - 1 Dec 2016

Ayers Jacob I, Diamond Jeffrey, Sari Adriana, Fromholt Susan, Galaleldeen Ahmad, Ostrow Lyle W, Glass Jonathan D, Hart P John, Borchelt David R

Abstract excerpt

Evidence of misfolded wild-type superoxide dismutase 1 (SOD1) has been detected in spinal cords of sporadic ALS (sALS) patients, suggesting an etiological relationship to SOD1-associated familial ALS (fALS). Given that there are currently a number of promising therapies under development that target SOD1, it is of critical importance to better understand the role of misfolded SOD1 in sALS. We previously...

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Identifiers

PMID: 27704280
DOI: 10.1007/s00401-016-1623-4
PMCID: PMC5107152

Genes

SOD1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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