Article
Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.
Cell death and differentiation - 1 Dec 2016
Rohrbeck Leona, Gong Jia-Nan, Lee Erinna F, Kueh Andrew J, Behren Andreas, Tai Lin, Lessene Guillaume, Huang David C S, Fairlie Walter D, Strasser Andreas, Herold Marco J
Abstract excerpt
A large proportion of melanomas harbour the activating BRAFV600E mutation that renders these cells dependent on MAPK signalling for their survival. Although the highly specific and clinically approved BRAFV600E kinase inhibitor, PLX4032, induces apoptosis of melanoma cells bearing this mutation, the underlying molecular mechanisms are not fully understood. Here, we reveal that PLX4032-induced apoptosis depends on...
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