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Article

Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy.

Circulation - 29 Nov 2016

Helms Adam S, Alvarado Francisco J, Yob Jaime, Tang Vi T, Pagani Francis, Russell Mark W, Valdivia Héctor H, Day Sharlene M

Abstract excerpt

BACKGROUND: Aberrant calcium signaling may contribute to arrhythmias and adverse remodeling in hypertrophic cardiomyopathy (HCM). Mutations in sarcomere genes may distinctly alter calcium handling pathways. METHODS: We analyzed gene expression, protein levels, and functional assays for calcium regulatory pathways in human HCM surgical samples with (n=25) and without (n=10) sarcomere mutations compared with...

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Source

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Identifiers

PMID: 27688314
DOI: 10.1161/CIRCULATIONAHA.115.020086
PMCID: PMC5127749

Genes

RCAN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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