Article
An accurate, simple prognostic model consisting of age, JAK2, CALR, and MPL mutation status for patients with primary myelofibrosis.
Haematologica - 1 Jan 2017
Rozovski Uri, Verstovsek Srdan, Manshouri Taghi, Dembitz Vilma, Bozinovic Ksenija, Newberry Kate, Zhang Ying, Bove Joseph E, Pierce Sherry, Kantarjian Hagop, Estrov Zeev
Abstract excerpt
In most patients with primary myelofibrosis, one of three mutually exclusive somatic mutations is detected. In approximately 60% of patients, the Janus kinase 2 gene is mutated, in 20%, the calreticulin gene is mutated, and in 5%, the myeloproliferative leukemia virus gene is mutated. Although patients with mutated calreticulin or myeloproliferative leukemia genes have a favorable outcome, and those with none of...
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