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Article

Cancer stem cells: A product of clonal evolution?

International journal of cancer - 1 Mar 2017

van Niekerk Gustav, Davids Lester M, Hattingh Suzèl M, Engelbrecht Anna-Mart

Abstract excerpt

The cancer stem cell (CSC) model has emerged as a prominent paradigm for explaining tumour heterogeneity. CSCs in tumour recurrence and drug resistance have also been implicated in a number of studies. In fact, CSCs are often identified by their expression of drug-efflux proteins which are also highly expressed in normal stem cells. Similarly, pro-survival or proliferation signalling often exhibited by stem cells...

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Identifiers

PMID: 27676693
DOI: 10.1002/ijc.30448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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