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Article

Validity of using ad hoc methods to analyze secondary traits in case-control association studies.

Genetic epidemiology - 1 Dec 2016

Yung Godwin, Lin Xihong

Abstract excerpt

Case-control association studies often collect from their subjects information on secondary phenotypes. Reusing the data and studying the association between genes and secondary phenotypes provide an attractive and cost-effective approach that can lead to discovery of new genetic associations. A number of approaches have been proposed, including simple and computationally efficient ad hoc methods that ignore...

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PMID: 27670932
DOI: 10.1002/gepi.21994
PMCID: PMC5170877

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