Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Trans-splicing improvement by the combined application of antisense strategies.

International journal of molecular sciences - 6 Jan 2015

Koller Ulrich, Hainzl Stefan, Kocher Thomas, Hüttner Clemens, Klausegger Alfred, Gruber Christina, Mayr Elisabeth, Wally Verena, Bauer Johann W, Murauer Eva M

Abstract excerpt

Spliceosome-mediated RNA trans-splicing has become an emergent tool for the repair of mutated pre-mRNAs in the treatment of genetic diseases. RNA trans-splicing molecules (RTMs) are designed to induce a specific trans-splicing reaction via a binding domain for a respective target pre-mRNA region....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Collagen Type VII
Share to Epidermolysis Bullosa
Share to Green Fluorescent Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Introns

Share to Mutation

Share to Oligonucleotides, Antisense

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 25569093
DOI: 10.3390/ijms16011179
PMCID: PMC4307297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25569093-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Trans-splicing improvement by the combined application of antisense strategies.PMID 25569093Read ↗

A reporter-based screen to identify potent 3' trans-splicing molecules for endogenous RNA repair.Semantic proximity Read ↗

Designing Efficient Double RNA trans-Splicing Molecules for Targeted RNA Repair.Semantic proximity Read ↗

Genetic therapies for RNA mis-splicing diseases.Semantic proximity Read ↗

Construction and validation of an RNA trans-splicing molecule suitable to repair a large number of COL7A1 mutations.Semantic proximity Read ↗

Splice modulation strategy applied to deep intronic variants in COL7A1 causing recessive dystrophic epidermolysis bullosaSemantic proximity Read ↗

Gene therapy progress and prospects: reprograming gene expression by trans-splicing.Semantic proximity Read ↗

COL7A1 Editing via RNA Trans-Splicing in RDEB-Derived Skin Equivalents.Semantic proximity Read ↗

Antisense-mediated exon skipping to reframe transcripts.Semantic proximity Read ↗

Splicing Modulation via Antisense Oligonucleotides in Recessive Dystrophic Epidermolysis BullosaSemantic proximity Read ↗

K14 mRNA reprogramming for dominant epidermolysis bullosa simplex.Semantic proximity Read ↗

Spliceosome-mediated trans-splicing: the therapeutic cut and paste.Semantic proximity Read ↗

Expansion of Splice-Switching Therapy with Antisense OligonucleotidesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.