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The Effects of Signal Erosion and Core Genome Reduction on the Identification of Diagnostic Markers

21 Sept 2016

Abstract excerpt

UNLABELLED: Whole-genome sequence (WGS) data are commonly used to design diagnostic targets for the identification of bacterial pathogens. To do this effectively, genomics databases must be comprehensive to identify the strict core genome that is specific to the target pathogen. As additional genomes are analyzed, the core genome size is reduced and there is erosion of the target-specific regions due to...

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PMID: 27651357
DOI: 10.1128/mbio.00846-16

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