Article
Pangenome Analysis of Burkholderia pseudomallei: Genome Evolution Preserves Gene Order despite High Recombination Rates.
PloS one - 1 Jan 2015
Spring-Pearson Senanu M, Stone Joshua K, Doyle Adina, Allender Christopher J, Okinaka Richard T, Mayo Mark, Broomall Stacey M, Hill Jessica M, Karavis Mark A, Hubbard Kyle S, Insalaco Joseph M, McNew Lauren A, Rosenzweig C Nicole, Gibbons Henry S, Currie Bart J, Wagner David M, Keim Paul, Tuanyok Apichai
Abstract excerpt
The pangenomic diversity in Burkholderia pseudomallei is high, with approximately 5.8% of the genome consisting of genomic islands. Genomic islands are known hotspots for recombination driven primarily by site-specific recombination associated with tRNAs. However, recombination rates in other portions of the genome are also high, a feature we expected to disrupt gene order. We analyzed the pangenome of 37...
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