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Article

A simple and cost-saving phenotypic drug susceptibility testing of HIV-1.

Scientific reports - 19 Sept 2016

Weng Yunceng, Zhang Ling, Huang Jianfeng, Zhao Jin, Luo Peifang, Bi Siyuan, Yang Zhengrong, Zhu Hai, Allain Jean-Pierre, Li Chengyao

Abstract excerpt

It is essential to monitor the occurrence of drug-resistant strains and to provide guidance for clinically adapted antiviral treatment of HIV/AIDS. In this study, an individual patient's HIV-1 pol gene encoding the full length of protease and part of the reverse transcriptase was packaged into a modified lentivirus carrying dual-reporters ZsGreen and luciferase. The optimal coefficient of correlation between drug...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Resistance, Viral

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Identifiers

PMID: 27640883
DOI: 10.1038/srep33559
PMCID: PMC5027539

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