Article
Phenotypic analysis of HIV-1 genotypic drug-resistant isolates from China, using a single-cycle system.
Molecular diagnosis & therapy - 1 Oct 2011
Jia Zheng, Xu Sihong, Nie Jianhui, Li Jingyun, Zhong Ping, Wang Wenbo, Wang Youchun
Abstract excerpt
BACKGROUND AND OBJECTIVES: Drug resistance in HIV-1 is one of the main causes of failure of antiretroviral therapy. Phenotypic detection of drug-resistant HIV-1 can provide guidance in selecting the optimal treatment regimen. Traditional phenotype assays are labor intensive and time consuming. Thus, a rapid and convenient phenotype assay with a single cycle of replication was developed and used in this study....
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