Article
Differential Expression of miR-4520a Associated With Pyrin Mutations in Familial Mediterranean Fever (FMF).
Journal of cellular physiology - 1 Jun 2017
Latsoudis Helen, Mashreghi Mir-Farzin, Grün Joachim R, Chang Hyun-Dong, Stuhlmüller Bruno, Repa Argyro, Gergiannaki Irini, Kabouraki Eleni, Vlachos George S, Häupl Thomas, Radbruch Andreas, Sidiropoulos Prodromos, Doukoumetzidis Kimon, Kardassis Dimitris, Niewold Timothy B, Boumpas Dimitrios T, Goulielmos George N
Abstract excerpt
Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent, acute, and self-limiting attacks of fever. Mutations in MEFV gene encoding pyrin account for FMF, but the high number of heterozygote patients with typical symptoms of the disease has driven a number of alternative aetiopathogenic hypotheses. The MEFV gene was knocked down in human myelomonocytic cells that express...
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