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Article

MEK Inhibitor Suppresses Expression of the miR-17-92 Cluster with G1-Phase Arrest in HT-29 Human Colon Cancer Cells and MIA PaCa-2 Pancreatic Cancer Cells.

Anticancer research - 1 Sept 2016

Tanaka Ryoichi, Tomosugi Mitsuhiro, Sakai Toshiyuki, Sowa Yoshihiro

Abstract excerpt

BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs, and the deregulated expression of miRNAs is associated with tumor development. Among these, the miR-17-92 cluster, including six mature miRNAs, is known as an oncogenic miRNA cluster because expression of the miR-17-92 cluster is frequently elevated in a variety of malignant tumors. MATERIALS AND METHODS: We investigated whether a mitogen-activated protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27630293
DOI: 10.21873/anticanres.11001

Genes

MIA
PTEN

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