Article
Feline Immunodeficiency Virus Vif N-Terminal Residues Selectively Counteract Feline APOBEC3s.
Journal of virology - 1 Dec 2016
Gu Qinyong, Zhang Zeli, Cano Ortiz Lucía, Franco Ana Cláudia, Häussinger Dieter, Münk Carsten
Abstract excerpt
Feline immunodeficiency virus (FIV) Vif protein counteracts feline APOBEC3s (FcaA3s) restriction factors by inducing their proteasomal degradation. The functional domains in FIV Vif for interaction with FcaA3s are poorly understood. Here, we have identified several motifs in FIV Vif that are important for selective degradation of different FcaA3s. Cats (Felis catus) express three types of A3s: single-domain A3Z2,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
