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Article

Clinical implications of routine genomic mutation sequencing in PIK3CA/AKT1 and KRAS/NRAS/BRAF in metastatic breast cancer.

Breast cancer research and treatment - 1 Nov 2016

Cejalvo Juan Miguel, Pérez-Fidalgo J Alejandro, Ribas Gloria, Burgués Octavio, Mongort Cristina, Alonso Elisa, Ibarrola-Villava Maider, Bermejo Begoña, Martínez María Teresa, Cervantes Andrés, Lluch Ana

Abstract excerpt

BACKGROUND: There is increasing interest in the molecular profiling of tumour tissues in order to investigate alternative breast cancer (BC) therapies. However, the impact of genomic screening for druggable mutations with targeted gene panel sequencing (TGPS) in routine practice remains controversial. METHODS: This is a retrospective analysis of data from a genomic screening programme at our institution, in which...

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Source

Identifiers

PMID: 27628192
DOI: 10.1007/s10549-016-3980-z

Genes

AKT1
BRAF
KRAS
NRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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