Article
Patterns of CRISPR/Cas9 activity in plants, animals and microbes.
Plant biotechnology journal - 1 Dec 2016
Bortesi Luisa, Zhu Changfu, Zischewski Julia, Perez Lucia, Bassié Ludovic, Nadi Riad, Forni Giobbe, Lade Sarah Boyd, Soto Erika, Jin Xin, Medina Vicente, Villorbina Gemma, Muñoz Pilar, Farré Gemma, Fischer Rainer, Twyman Richard M, Capell Teresa, Christou Paul, Schillberg Stefan
Abstract excerpt
The CRISPR/Cas9 system and related RNA-guided endonucleases can introduce double-strand breaks (DSBs) at specific sites in the genome, allowing the generation of targeted mutations in one or more genes as well as more complex genomic rearrangements. Modifications of the canonical CRISPR/Cas9 syst...
Topics
- Animals
- CRISPR-Cas Systems
- Endonucleases
- Gene Editing
- Humans
- Mutagenesis, Site-Directed
- Mutation
- RNA Editing