Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer.

doi:10.1186/s13046-016-0410-3

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Article

Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer.

Journal of experimental & clinical cancer research : CR - 6 Sept 2016

Prodosmo Andrea, Buffone Amelia, Mattioni Manlio, Barnabei Agnese, Persichetti Agnese, De Leo Aurora, Appetecchia Marialuisa, Nicolussi Arianna, Coppa Anna, Sciacchitano Salvatore, Giordano Carolina, Pinnarò Paola, Sanguineti Giuseppe, Strigari Lidia, Alessandrini Gabriele, Facciolo Francesco, Cosimelli Maurizio, Grazi Gian Luca, Corrado Giacomo, Vizza Enrico, Giannini Giuseppe, Soddu Silvia

Abstract excerpt

BACKGROUND: Variant ATM heterozygotes have an increased risk of developing cancer, cardiovascular diseases, and diabetes. Costs and time of sequencing and ATM variant complexity make large-scale, general population screenings not cost-effective yet. Recently, we developed a straightforward, rapid, and inexpensive test based on p53 mitotic centrosomal localization (p53-MCL) in peripheral blood mononuclear cells...

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Identifiers

PMID: 27599564
DOI: 10.1186/s13046-016-0410-3
PMCID: PMC5012020

Genes

ATM
BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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