Article
Qualitative Dynamical Modelling Can Formally Explain Mesoderm Specification and Predict Novel Developmental Phenotypes.
PLoS computational biology - 1 Sept 2016
Mbodj Abibatou, Gustafson E Hilary, Ciglar Lucia, Junion Guillaume, Gonzalez Aitor, Girardot Charles, Perrin Laurent, Furlong Eileen E M, Thieffry Denis
Abstract excerpt
Given the complexity of developmental networks, it is often difficult to predict the effect of genetic perturbations, even within coding genes. Regulatory factors generally have pleiotropic effects, exhibit partially redundant roles, and regulate highly interconnected pathways with ample cross-talk. Here, we delineate a logical model encompassing 48 components and 82 regulatory interactions involved in mesoderm...
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