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Article

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

28 Oct 2011

Abstract excerpt

Cytotoxic chemotherapy targets elements common to all nucleated human cells, such as DNA and microtubules, yet it selectively kills tumor cells. Here we show that clinical response to these drugs correlates with, and may be partially governed by, the pretreatment proximity of tumor cell mitochondria to the apoptotic threshold, a property called mitochondrial priming. We used BH3 profiling to measure priming in...

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PMID: 22033517
DOI: 10.1126/science.1206727

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