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Article

Cabozantinib Induces Isolated Hyperbilirubinemia in Renal Cell Carcinoma Patients carrying the UGT1A1*28 Polymorphism.

Clinical genitourinary cancer - 1 Oct 2024

Mobaraki Sajedeh, Nissen Peter Henrik, Donskov Frede, Wozniak Agnieszka, Van Herck Yannick, Coosemans Lina, van Nieuwenhuyse Tine, Lambrechts Diether, Bechter Oliver, Baldewijns Marcella, Roussel Eduard, Laenen Annouschka, Beuselinck Benoit

Abstract excerpt

BACKGROUND: Genetic variants of UGT1A1, involved in glucuronidation and clearance of bilirubin, are associated with reduced bilirubin metabolization and drug-induced isolated hyperbilirubinemia. We studied the impact of the UGT1A1*28 polymorphism on drug-induced isolated hyperbilirubinemia in metastatic renal cell carcinoma patients treated with pazopanib, cabozantinib, and axitinib. METHODS: We genotyped the...

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Anilides
Bilirubin
Carcinoma, Renal Cell
Glucuronosyltransferase
Hyperbilirubinemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39155162
DOI: 10.1016/j.clgc.2024.102180

Genes

UGT1A1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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