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Article

Gemcitabine treatment promotes pancreatic cancer stemness through the Nox/ROS/NF-κB/STAT3 signaling cascade.

Cancer letters - 1 Nov 2016

Zhang Zhengle, Duan Qingke, Zhao Hengqiang, Liu Tao, Wu Heshui, Shen Qiang, Wang Chunyou, Yin Tao

Abstract excerpt

Gemcitabine, the standard chemotherapy drug for advanced pancreatic cancer, has shown limited benefits because of profound chemoresistance. However, the mechanism involved remains unclear. Cancer stem cells exhibit great tumorigenicity and are closely correlated with drug resistance and tumor relapse. In this study, we demonstrated that certain doses of gemcitabine increased the ratios of CD24+ and CD133+ cells...

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Source

Identifiers

PMID: 27576197
DOI: 10.1016/j.canlet.2016.08.023

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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