Article
Homozygous DNAH1 frameshift mutation causes multiple morphological anomalies of the sperm flagella in Chinese.
Clinical genetics - 1 Feb 2017
Wang X, Jin H, Han F, Cui Y, Chen J, Yang C, Zhu P, Wang W, Jiao G, Wang W, Hao C, Gao Z
Abstract excerpt
This study aimed to investigate the genetic pathogeny of multiple morphological anomalies of the flagella (MMAF), which is a genetically heterogeneous disorder leading to male infertility. Nine patients with severe asthenozoospermia caused by MMAF were recruited. Whole genome sequencing and Sanger sequencing were performed, and we found that four of the nine patients were affected by the same homozygous...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.