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Article

GLI inhibitor GANT61 kills melanoma cells and acts in synergy with obatoclax.

International journal of oncology - 1 Sept 2016

Vlčková Kateřina, Réda Jiri, Ondrušová Lubica, Krayem Mohammad, Ghanem Ghanem, Vachtenheim Jiri

Abstract excerpt

MEK kinase inhibitors (trametinib and selumetinib) or kinase inhibitors directed against mutated BRAF(V600E) (vemurafenib and dabrafenib) have initial encouraging effects in the treatment of melanoma but acquired resistance appears almost invariably after some months. Studies revealed mutually exclusive NRAS and BRAF activating mutations driving the MAPK/ERK pathway among human melanomas. Although combination...

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Identifiers

PMID: 27572939
DOI: 10.3892/ijo.2016.3596

Genes

BRAF
BCL2
NRAS
GLI1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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