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Article

PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A.

Cancer letters - 1 Nov 2018

Liu Yifan, Yang Eun Ju, Zhang Baoyuan, Miao Zhengqiang, Wu Changjie, Lyu Junfang, Tan Kaeling, Poon Terence Chuen Wai, Shim Joong Sup

Abstract excerpt

PTEN is a tumor suppressor found mutated in many cancers. From a synthetic lethality drug screen with PTEN-isogenic colorectal cancer cells, we found that mutant-PTEN cells were resistant to dual inhibitors of FLT3 and aurora kinase-A, including KW2449 and ENMD-2076. KW2449 significantly reduced the viability of wildtype-PTEN cells causing apoptosis, while little effect was observed in mutant-PTEN counterparts....

Topics

Animals
Antineoplastic Combined Chemotherapy Protocols
Aurora Kinase A
Cell Line, Tumor
Colorectal Neoplasms
Drug Resistance, Neoplasm
Female
HCT116 Cells
Humans
Indazoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Nude

Mutation

PTEN Phosphohydrolase

Phosphatidylinositol 3-Kinases

Phosphorylation

Piperazines

Proto-Oncogene Proteins c-akt

Pyrazoles

Source

Identifiers

PMID: 30118842
DOI: 10.1016/j.canlet.2018.08.011

Genes

PTEN
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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