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ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling

23 Aug 2016

Abstract excerpt

The transcription factor Nrf2 and its repressor protein Keap1 play key roles in the regulation of antioxidant stress responses and both Keap1-Nrf2 signalling and oxidative stress have been implicated in the pathogenesis of the ALS-FTLD spectrum of neurodegenerative disorders. The Keap1-binding partner and autophagy receptor SQSTM1/p62 has also recently been linked genetically to ALS-FTLD, with some missense...

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PMID: 27554286
DOI: 10.1016/j.mcn.2016.08.004

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