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Article

A bivariate genome-wide association study identifies ADAM12 as a novel susceptibility gene for Kashin-Beck disease.

Scientific reports - 22 Aug 2016

Hao Jingcan, Wang Wenyu, Wen Yan, Xiao Xiao, He Awen, Guo Xiong, Yang Tielin, Liu Xiaogang, Shen Hui, Chen Xiangding, Tian Qing, Deng Hong-Wen, Zhang Feng

Abstract excerpt

Kashin-Beck disease (KBD) is a chronic osteoarthropathy, which manifests as joint deformities and growth retardation. Only a few genetic studies of growth retardation associated with the KBD have been carried out by now. In this study, we conducted a two-stage bivariate genome-wide association study (BGWAS) of the KBD using joint deformities and body height as study phenotypes, totally involving 2,417 study...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27545300
DOI: 10.1038/srep31792
PMCID: PMC4992896

Genes

ADAM12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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