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Article

FANCM c.5101C>T mutation associates with breast cancer survival and treatment outcome.

International journal of cancer - 15 Dec 2016

Kiiski Johanna I, Fagerholm Rainer, Tervasmäki Anna, Pelttari Liisa M, Khan Sofia, Jamshidi Maral, Mantere Tuomo, Pylkäs Katri, Bartek Jiri, Bartkova Jirina, Mannermaa Arto, Tengström Maria, Kosma Veli-Matti, Winqvist Robert, Kallioniemi Anne, Aittomäki Kristiina, Blomqvist Carl, Nevanlinna Heli

Abstract excerpt

Breast cancer (BC) is a heterogeneous disease, and different tumor characteristics and genetic variation may affect the clinical outcome. The FANCM c.5101C > T nonsense mutation in the Finnish population associates with increased risk of breast cancer, especially for triple-negative breast cancer patients. To investigate the association of the mutation with disease prognosis, we studied tumor phenotype, treatment...

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Identifiers

PMID: 27542569
DOI: 10.1002/ijc.30394
PMCID: PMC5095781

Genes

FANCM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FANCM c.5101C>T mutation associates with breast cancer survival and treatment outcome.PMID 27542569Read ↗

Exome sequencing identifies FANCM as a susceptibility gene for triple-negative breast cancer.Semantic proximity Read ↗

FANCM mutation c.5791C>T is a risk factor for triple-negative breast cancer in the Finnish population.Semantic proximity Read ↗

Large-scale meta-analysis and precision functional assays identify FANCM regions in which PTVs confer different risks for ER-negative and triple-negative breast cancer.Semantic proximity Read ↗

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancerSemantic proximity Read ↗

FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women.Semantic proximity Read ↗

Homozygous FANCM Variant c.5101C>T p.(Gln1701*) in a Patient With Early Onset Breast Cancer, Chemotherapy Toxicity, and Chromosome Fragility: A Case Report.Semantic proximity Read ↗

Homozygous FANCM variant c.5101C>T p.(Gln1701*) in a patient with early onset breast cancer, chemotherapy toxicity, and chromosome fragilitySemantic proximity Read ↗

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Association of FANCM Mutations with Familial and Early-Onset Breast Cancer Risk in a South American Population.Semantic proximity Read ↗

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