Article
Angiotensin II Type 1 Receptor Knockdown Impairs Interleukin-1β-Induced Cytokines in Human Periodontal Fibroblasts.
Journal of periodontology - 1 Jan 2017
Gabriele Lilian Gobbo, Morandini Ana Carolina, Dionísio Thiago José, Santos Carlos Ferreira
Abstract excerpt
BACKGROUND: The renin-angiotensin (Ang) system (RAS) has been reported as an important modulator of inflammatory and immune responses. Evidence suggests an alternative Ang 1-7/Mas receptor axis as counter-regulatory to the classic RAS Ang II/Ang II Type 1 (AT1) receptor axis. It is known that periodontal pathogens elicit host-derived immune response due to release of cytokines such as interleukin (IL)-1β, and...
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